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- Giacomini K, Yee SW, Ferrández-Peral L, Alentorn P, Fontsere C, Ceylan M, Koleske M, Handin N, Artegoitia V, Lara G, Chien HC, Zhou X, Dainat J, Zalevsky A, Sali A, Brand C, Capra J, Artursson P, Newman J, Marques-Bonet T. Illuminating the Function of the Orphan Transporter, SLC22A10 in Humans and Other Primates. Res Sq. 2023 Sep 14. View in PubMed
- Michel ME, Wen CC, Yee SW, Giacomini KM, Hamdoun A, Nicklisch SCT. TICBase: Integrated Resource for Data on Drug and Environmental Chemical Interactions with Mammalian Drug Transporters. Clin Pharmacol Ther. 2023 Sep 01. View in PubMed
- Wu B, Yee SW, Xiao S, Xu F, Sridhar SB, Yang M, Hochstadt S, Cabral W, Lanfear DE, Hedderson MM, Giacomini KM, Williams LK. Genome-Wide Association Study Identifies Pharmacogenomic Variants Associated With Metformin Glycemic Response in African American Patients With Type 2 Diabetes. Diabetes Care. 2023 Aug 28. View in PubMed
- Yee SW, Ferrández-Peral L, Alentorn P, Fontsere C, Ceylan M, Koleske ML, Handin N, Artegoitia VM, Lara G, Chien HC, Zhou X, Dainat J, Zalevsky A, Sali A, Brand CM, Capra JA, Artursson P, Newman JW, Marques-Bonet T, Giacomini KM. Illuminating the Function of the Orphan Transporter, SLC22A10 in Humans and Other Primates. bioRxiv. 2023 Aug 12. View in PubMed
- Wen A, Zhu Y, Yee SW, Park BI, Giacomini KM, Greenberg AS, Newman JW. The Impacts of Slc19a3 Deletion and Intestinal SLC19A3 Insertion on Thiamine Distribution and Brain Metabolism in the Mouse. Metabolites. 2023 Jul 26; 13(8). View in PubMed
- Lin TY, Mai QN, Zhang H, Wilson E, Chien HC, Yee SW, Giacomini KM, Olgin JE, Irannejad R. Cardiac contraction and relaxation are regulated by distinct subcellular cAMP pools. Nat Chem Biol. 2023 Jul 20. View in PubMed
- Minichmayr IK, Smith DM, Giacomini KM, van der Graaf PH. Trends in Clinical Pharmacology and Therapeutics. Clin Pharmacol Ther. 2023 07; 114(1):11-14. View in PubMed
- Yee SW, Macdonald C, Mitrovic D, Zhou X, Koleske ML, Yang J, Silva DB, Grimes PR, Trinidad D, More SS, Kachuri L, Witte JS, Delemotte L, Giacomini KM, Coyote-Maestas W. The full spectrum of OCT1 (SLC22A1) mutations bridges transporter biophysics to drug pharmacogenomics. bioRxiv. 2023 Jun 07. View in PubMed
- Azimi M, Yee SW, Riselli A, Silva DB, Giacomini CP, Giacomini KM, Brett CM. Characterization of P-glycoprotein orthologs from human, sheep, pig, dog, and cat. J Vet Pharmacol Ther. 2023 Nov; 46(6):401-412. View in PubMed
- Vora B, Wen A, Yee SW, Trinh K, Azimi M, Green EAE, Sirota M, Greenberg AS, Newman JW, Giacomini KM. The Effect of Trimethoprim on Thiamine Absorption: A Transporter-Mediated Drug-Nutrient Interaction. Clin Pharmacol Ther. 2023 08; 114(2):381-392. View in PubMed
- Giacomini KM. Biomarkers Come of Age in Clinical Pharmacology. Clin Pharmacol Ther. 2023 05; 113(5):945-947. View in PubMed
- Venkatakrishnan K, Brown KE, Giacomini KM, van der Graaf PH. Diversity, Equity, and Inclusion: Translating Clinical Pharmacology for All. Clin Pharmacol Ther. 2023 03; 113(3):457-461. View in PubMed
- Li JH, Perry JA, Jablonski KA, Srinivasan S, Chen L, Todd JN, Harden M, Mercader JM, Pan Q, Dawed AY, Yee SW, Pearson ER, Giacomini KM, Giri A, Hung AM, Xiao S, Williams LK, Franks PW, Hanson RL, Kahn SE, Knowler WC, Pollin TI, Florez JC, Diabetes Prevention Program Research Group:. Identification of Genetic Variation Influencing Metformin Response in a Multiancestry Genome-Wide Association Study in the Diabetes Prevention Program (DPP). Diabetes. 2023 08 01; 72(8):1161-1172. View in PubMed
- Koleske ML, McInnes G, Brown JEH, Thomas N, Hutchinson K, Chin MY, Koehl A, Arkin MR, Schlessinger A, Gallagher RC, Song YS, Altman RB, Giacomini KM. Functional genomics of OCTN2 variants informs protein-specific variant effect predictor for Carnitine Transporter Deficiency. Proc Natl Acad Sci U S A. 2022 Nov 16; 119(46):e2210247119. View in PubMed
- Giacomini KM, Huang SM. More Than Pharmacokinetics: Transporters in Clinical Pharmacology. Clin Pharmacol Ther. 2022 09; 112(3):423-426. View in PubMed
- Martinez MN, Sinko B, Wu F, Flanagan T, Borbás E, Tsakalozou E, Giacomini KM. A Critical Overview of the Biological Effects of Excipients (Part I): Impact on Gastrointestinal Absorption. AAPS J. 2022 05 02; 24(3):60. View in PubMed
- Giacomini KM, Yee SW, Koleske ML, Zou L, Matsson P, Chen EC, Kroetz DL, Miller MA, Gozalpour E, Chu X. New and Emerging Research on Solute Carrier and ATP Binding Cassette Transporters in Drug Discovery and Development: Outlook From the International Transporter Consortium. Clin Pharmacol Ther. 2022 09; 112(3):540-561. View in PubMed
- Dawed AY, Yee SW, Zhou K, van Leeuwen N, Zhang Y, Siddiqui MK, Etheridge A, Innocenti F, Xu F, Li JH, Beulens JW, van der Heijden AA, Slieker RC, Chang YC, Mercader JM, Kaur V, Witte JS, Lee MTM, Kamatani Y, Momozawa Y, Kubo M, Palmer CNA, Florez JC, Hedderson MM, 't Hart LM, Giacomini KM, Pearson ER, for MetGen Plus, for the DIRECT Consortium. Response to Comment on Dawed et al. Genome-Wide Meta-analysis Identifies Genetic Variants Associated With Glycemic Response to Sulfonylureas. Diabetes Care 2021;44:2673-2682. Diabetes Care. 2022 04 01; 45(4):e82-e83. View in PubMed
- Giacomini KM, van der Graaf PH. The Pandemic as a Catalyst for Disruptive Innovation in Clinical Pharmacology. Clin Pharmacol Ther. 2022 03; 111(3):529-532. View in PubMed
- Cooper-DeHoff RM, Niemi M, Ramsey LB, Luzum JA, Tarkiainen EK, Straka RJ, Gong L, Tuteja S, Wilke RA, Wadelius M, Larson EA, Roden DM, Klein TE, Yee SW, Krauss RM, Turner RM, Palaniappan L, Gaedigk A, Giacomini KM, Caudle KE, Voora D. The Clinical Pharmacogenetics Implementation Consortium Guideline for SLCO1B1, ABCG2, and CYP2C9 genotypes and Statin-Associated Musculoskeletal Symptoms. Clin Pharmacol Ther. 2022 05; 111(5):1007-1021. View in PubMed
- Chen EC, Matsson P, Azimi M, Zhou X, Handin N, Yee SW, Artursson P, Giacomini KM. High Throughput Screening of a Prescription Drug Library for Inhibitors of Organic Cation Transporter 3, OCT3. Pharm Res. 2022 Jul; 39(7):1599-1613. View in PubMed
- Yee SW, Giacomini KM. Emerging Roles of the Human Solute Carrier 22 Family. Drug Metab Dispos. 2021 Dec 17. View in PubMed
- Dawed AY, Yee SW, Zhou K, van Leeuwen N, Zhang Y, Siddiqui MK, Etheridge A, Innocenti F, Xu F, Li JH, Beulens JW, van der Heijden AA, Slieker RC, Chang YC, Mercader JM, Kaur V, Witte JS, Lee MTM, Kamatani Y, Momozawa Y, Kubo M, Palmer CNA, Florez JC, Hedderson MM, 't Hart LM, Giacomini KM, Pearson ER, for MetGen Plus, for the DIRECT Consortium, MetGen Plus investigators:. Genome-Wide Meta-analysis Identifies Genetic Variants Associated With Glycemic Response to Sulfonylureas. Diabetes Care. 2021 12; 44(12):2673-2682. View in PubMed
- Bajaj R, Chong LB, Zou L, Tsakalozou E, Ni Z, Giacomini KM, Kroetz DL. Interaction of Commonly Used Oral Molecular Excipients with P-glycoprotein. AAPS J. 2021 09 15; 23(5):106. View in PubMed
- Giacomini KM, Karnes JH, Crews KR, Monte AA, Murphy WA, Oni-Orisan A, Ramsey LB, Yang JJ, Whirl-Carrillo M. Advancing Precision Medicine Through the New Pharmacogenomics Global Research Network. Clin Pharmacol Ther. 2021 09; 110(3):559-562. View in PubMed
- Yee SW, Vora B, Oskotsky T, Zou L, Jakobsen S, Enogieru OJ, Koleske ML, Kosti I, Rödin M, Sirota M, Giacomini KM. Drugs in COVID-19 Clinical Trials: Predicting Transporter-Mediated Drug-Drug Interactions Using In Vitro Assays and Real-World Data. Clin Pharmacol Ther. 2021 07; 110(1):108-122. View in PubMed
- Vora B, Brackman DJ, Zou L, Garcia-Cremades M, Sirota M, Savic RM, Giacomini KM. Oxypurinol pharmacokinetics and pharmacodynamics in healthy volunteers: Influence of BCRP Q141K polymorphism and patient characteristics. Clin Transl Sci. 2021 07; 14(4):1431-1443. View in PubMed
- McInnes G, Sharo AG, Koleske ML, Brown JEH, Norstad M, Adhikari AN, Wang S, Brenner SE, Halpern J, Koenig BA, Magnus DC, Gallagher RC, Giacomini KM, Altman RB. Opportunities and challenges for the computational interpretation of rare variation in clinically important genes. Am J Hum Genet. 2021 04 01; 108(4):535-548. View in PubMed
- Enogieru OJ, Koleske ML, Vora B, Ngo H, Yee SW, Chatad D, Sirota M, Giacomini KM. The Effects of Genetic Mutations and Drugs on the Activity of the Thiamine Transporter, SLC19A2. AAPS J. 2021 03 01; 23(2):35. View in PubMed
- Lavertu A, Vora B, Giacomini KM, Altman R, Rensi S. A New Era in Pharmacovigilance: Toward Real-World Data and Digital Monitoring. Clin Pharmacol Ther. 2021 05; 109(5):1197-1202. View in PubMed
- Neul C, Hofmann U, Schaeffeler E, Winter S, Klein K, Giacomini KM, Eichelbaum M, Schwab M, Nies AT. Characterization of cytochrome P450 (CYP) 2D6 drugs as substrates of human organic cation transporters and multidrug and toxin extrusion proteins. Br J Pharmacol. 2021 03; 178(6):1459-1474. View in PubMed
- Yee SW, Buitrago D, Stecula A, Ngo HX, Chien HC, Zou L, Koleske ML, Giacomini KM. Deorphaning a solute carrier 22 family member, SLC22A15, through functional genomic studies. FASEB J. 2020 12; 34(12):15734-15752. View in PubMed
- Matsson P, Baranczewski P, Giacomini KM, Andersson TB, Palm J, Palm K, Charman WN, Bergström CAS. A Tribute to Professor Per Artursson - Scientist, Explorer, Mentor, Innovator, and Giant in Pharmaceutical Research. J Pharm Sci. 2021 01; 110(1):2-11. View in PubMed
- Zou L, Matsson P, Stecula A, Ngo HX, Zur AA, Giacomini KM. Drug Metabolites Potently Inhibit Renal Organic Anion Transporters, OAT1 and OAT3. J Pharm Sci. 2021 01; 110(1):347-353. View in PubMed
- Wilson JL, Cheung KWK, Lin L, Green EAE, Porrás AI, Zou L, Mukanga D, Akpa PA, Darko DM, Yuan R, Ding S, Johnson WCN, Lee HA, Cooke E, Peck CC, Kern SE, Hartman D, Hayashi Y, Marks PW, Altman RB, Lumpkin MM, Giacomini KM, Blaschke TF. Scientific considerations for global drug development. Sci Transl Med. 2020 07 29; 12(554). View in PubMed
- Pottel J, Armstrong D, Zou L, Fekete A, Huang XP, Torosyan H, Bednarczyk D, Whitebread S, Bhhatarai B, Liang G, Jin H, Ghaemi SN, Slocum S, Lukacs KV, Irwin JJ, Berg EL, Giacomini KM, Roth BL, Shoichet BK, Urban L. The activities of drug inactive ingredients on biological targets. Science. 2020 07 24; 369(6502):403-413. View in PubMed
- Lin L, Lemieux GA, Enogieru OJ, Giacomini KM, Ashrafi K. Neural production of kynurenic acid in Caenorhabditis elegans requires the AAT-1 transporter. Genes Dev. 2020 08 01; 34(15-16):1033-1038. View in PubMed
- van der Graaf PH, Giacomini KM. COVID-19: A Defining Moment for Clinical Pharmacology? Clin Pharmacol Ther. 2020 07; 108(1):11-15. View in PubMed
- Zou L, Spanogiannopoulos P, Pieper LM, Chien HC, Cai W, Khuri N, Pottel J, Vora B, Ni Z, Tsakalozou E, Zhang W, Shoichet BK, Giacomini KM, Turnbaugh PJ. Bacterial metabolism rescues the inhibition of intestinal drug absorption by food and drug additives. Proc Natl Acad Sci U S A. 2020 07 07; 117(27):16009-16018. View in PubMed
- Shahin MH, Giacomini KM. Oral Anticoagulants and Precision Medicine: Something Old, Something New. Clin Pharmacol Ther. 2020 06; 107(6):1273-1277. View in PubMed
- Giacomini KM. Novel Technologies Enable Mechanistic Understanding and Modeling of Drug Exposure and Response. Clin Pharmacol Ther. 2020 05; 107(5):1045-1047. View in PubMed
- Chang YC, Wu JT, Hong MY, Tung YA, Hsieh PH, Yee SW, Giacomini KM, Oyang YJ, Chen CY, Alzheimer’s Disease Neuroimaging Initiative. GenEpi: gene-based epistasis discovery using machine learning. BMC Bioinformatics. 2020 Feb 24; 21(1):68. View in PubMed
- Zou L, Pottel J, Khuri N, Ngo HX, Ni Z, Tsakalozou E, Warren MS, Huang Y, Shoichet BK, Giacomini KM. Interactions of Oral Molecular Excipients with Breast Cancer Resistance Protein, BCRP. Mol Pharm. 2020 03 02; 17(3):748-756. View in PubMed
- van der Graaf PH, Giacomini KM. Clinical Pharmacology & Therapeutics 2030. Clin Pharmacol Ther. 2020 01; 107(1):13-16. View in PubMed
- Vora B, Green EAE, Khuri N, Ballgren F, Sirota M, Giacomini KM. Drug-nutrient interactions: discovering prescription drug inhibitors of the thiamine transporter ThTR-2 (SLC19A3). Am J Clin Nutr. 2020 01 01; 111(1):110-121. View in PubMed
- Yee SW, Do TP, Huang SM, Krauss RM, Kusuhara H, Sugiyama Y, Unadkat JD, Giacomini KM. Expanding Precompetitive Multisector Collaborations to Advance Drug Development and Pharmacogenomics. Clin Pharmacol Ther. 2020 01; 107(1):96-101. View in PubMed
- Chenoweth MJ, Giacomini KM, Pirmohamed M, Hill SL, van Schaik RHN, Schwab M, Shuldiner AR, Relling MV, Tyndale RF. Global Pharmacogenomics Within Precision Medicine: Challenges and Opportunities. Clin Pharmacol Ther. 2020 01; 107(1):57-61. View in PubMed
- Yee SW, Stecula A, Chien HC, Zou L, Feofanova EV, van Borselen M, Cheung KWK, Yousri NA, Suhre K, Kinchen JM, Boerwinkle E, Irannejad R, Yu B, Giacomini KM. Unraveling the functional role of the orphan solute carrier, SLC22A24 in the transport of steroid conjugates through metabolomic and genome-wide association studies. PLoS Genet. 2019 09; 15(9):e1008208. View in PubMed
- Lang S, Hilsabeck TA, Wilson KA, Sharma A, Bose N, Brackman DJ, Beck JN, Chen L, Watson MA, Killilea DW, Ho S, Kahn A, Giacomini K, Stoller ML, Chi T, Kapahi P. A conserved role of the insulin-like signaling pathway in diet-dependent uric acid pathologies in Drosophila melanogaster. PLoS Genet. 2019 08; 15(8):e1008318. View in PubMed
- Cheung KWK, van Groen BD, Spaans E, van Borselen MD, de Bruijn ACJM, Simons-Oosterhuis Y, Tibboel D, Samsom JN, Verdijk RM, Smeets B, Zhang L, Huang SM, Giacomini KM, de Wildt SN. A Comprehensive Analysis of Ontogeny of Renal Drug Transporters: mRNA Analyses, Quantitative Proteomics, and Localization. Clin Pharmacol Ther. 2019 11; 106(5):1083-1092. View in PubMed
- Hall C, Wolfe H, Wells A, Chien HC, Colas C, Schlessinger A, Giacomini KM, Thomas AA. l-Type amino acid transporter 1 activity of 1,2,3-triazolyl analogs of l-histidine and l-tryptophan. Bioorg Med Chem Lett. 2019 08 15; 29(16):2254-2258. View in PubMed
- Brackman DJ, Yee SW, Enogieru OJ, Shaffer C, Ranatunga D, Denny JC, Wei WQ, Kamatani Y, Kubo M, Roden DM, Jorgenson E, Giacomini KM. Genome-Wide Association and Functional Studies Reveal Novel Pharmacological Mechanisms for Allopurinol. Clin Pharmacol Ther. 2019 09; 106(3):623-631. View in PubMed
- Enogieru OJ, Ung PMU, Yee SW, Schlessinger A, Giacomini KM. Functional and structural analysis of rare SLC2A2 variants associated with Fanconi-Bickel syndrome and metabolic traits. Hum Mutat. 2019 07; 40(7):983-995. View in PubMed
- Yee SW, Giacomini MM, Shen H, Humphreys WG, Horng H, Brian W, Lai Y, Kroetz DL, Giacomini KM. Organic Anion Transporter Polypeptide 1B1 Polymorphism Modulates the Extent of Drug-Drug Interaction and Associated Biomarker Levels in Healthy Volunteers. Clin Transl Sci. 2019 07; 12(4):388-399. View in PubMed
- Giacomini KM, Lin L, Altman RB. Research Projects Supported by the University of California, San Francisco-Stanford Center of Excellence in Regulatory Science and Innovation. Clin Pharmacol Ther. 2019 04; 105(4):815-818. View in PubMed
- Zou L, Ni Z, Tsakalozou E, Giacomini KM. Impact of Pharmaceutical Excipients on Oral Drug Absorption: A Focus on Intestinal Drug Transporters. Clin Pharmacol Ther. 2019 02; 105(2):323-325. View in PubMed
- Song W, Luo Q, Zhang Y, Zhou L, Liu Y, Ma Z, Guo J, Huang Y, Cheng L, Meng Z, Li Z, Zhang B, Li S, Yee SW, Fan H, Li P, Giacomini KM, Chen L. Organic cation transporter 3 (Oct3) is a distinct catecholamines clearance route in adipocytes mediating the beiging of white adipose tissue. PLoS Biol. 2019 01; 17(1):e2006571. View in PubMed
- Chu X, Liao M, Shen H, Yoshida K, Zur AA, Arya V, Galetin A, Giacomini KM, Hanna I, Kusuhara H, Lai Y, Rodrigues D, Sugiyama Y, Zamek-Gliszczynski MJ, Zhang L, International Transporter Consortium. Clinical Probes and Endogenous Biomarkers as Substrates for Transporter Drug-Drug Interaction Evaluation: Perspectives From the International Transporter Consortium. Clin Pharmacol Ther. 2018 11; 104(5):836-864. View in PubMed
- Giacomini KM, Galetin A, Huang SM. The International Transporter Consortium: Summarizing Advances in the Role of Transporters in Drug Development. Clin Pharmacol Ther. 2018 11; 104(5):766-771. View in PubMed
- Chien HC, Colas C, Finke K, Springer S, Stoner L, Zur AA, Venteicher B, Campbell J, Hall C, Flint A, Augustyn E, Hernandez C, Heeren N, Hansen L, Anthony A, Bauer J, Fotiadis D, Schlessinger A, Giacomini KM, Thomas AA. Reevaluating the Substrate Specificity of the L-Type Amino Acid Transporter (LAT1). J Med Chem. 2018 08 23; 61(16):7358-7373. View in PubMed
- Zamek-Gliszczynski MJ, Taub ME, Chothe PP, Chu X, Giacomini KM, Kim RB, Ray AS, Stocker SL, Unadkat JD, Wittwer MB, Xia C, Yee SW, Zhang L, Zhang Y, International Transporter Consortium. Transporters in Drug Development: 2018 ITC Recommendations for Transporters of Emerging Clinical Importance. Clin Pharmacol Ther. 2018 11; 104(5):890-899. View in PubMed
- Yee SW, Brackman DJ, Ennis EA, Sugiyama Y, Kamdem LK, Blanchard R, Galetin A, Zhang L, Giacomini KM. Influence of Transporter Polymorphisms on Drug Disposition and Response: A Perspective From the International Transporter Consortium. Clin Pharmacol Ther. 2018 11; 104(5):803-817. View in PubMed
- Zamek-Gliszczynski MJ, Chu X, Cook JA, Custodio JM, Galetin A, Giacomini KM, Lee CA, Paine MF, Ray AS, Ware JA, Wittwer MB, Zhang L, International Transporter Consortium. ITC Commentary on Metformin Clinical Drug-Drug Interaction Study Design That Enables an Efficacy- and Safety-Based Dose Adjustment Decision. Clin Pharmacol Ther. 2018 11; 104(5):781-784. View in PubMed
- Srinivasan S, Yee SW, Giacomini KM. Pharmacogenetics of Antidiabetic Drugs. Adv Pharmacol. 2018; 83:361-389. View in PubMed
- Zou L, Stecula A, Gupta A, Prasad B, Chien HC, Yee SW, Wang L, Unadkat JD, Stahl SH, Fenner KS, Giacomini KM. Molecular Mechanisms for Species Differences in Organic Anion Transporter 1, OAT1: Implications for Renal Drug Toxicity. Mol Pharmacol. 2018 07; 94(1):689-699. View in PubMed
- Liang X, Yee SW, Chien HC, Chen EC, Luo Q, Zou L, Piao M, Mifune A, Chen L, Calvert ME, King S, Norheim F, Abad J, Krauss RM, Giacomini KM. Organic cation transporter 1 (OCT1) modulates multiple cardiometabolic traits through effects on hepatic thiamine content. PLoS Biol. 2018 04; 16(4):e2002907. View in PubMed
- Rotroff DM, Yee SW, Zhou K, Marvel SW, Shah HS, Jack JR, Havener TM, Hedderson MM, Kubo M, Herman MA, Gao H, Mychaleckyi JC, McLeod HL, Doria A, Giacomini KM, Pearson ER, Wagner MJ, Buse JB, Motsinger-Reif AA, MetGen Investigators, ACCORD/ACCORDion Investigators. Genetic Variants in CPA6 and PRPF31 Are Associated With Variation in Response to Metformin in Individuals With Type 2 Diabetes. Diabetes. 2018 07; 67(7):1428-1440. View in PubMed
- Brackman DJ, Giacomini KM. Reverse Translational Research of ABCG2 (BCRP) in Human Disease and Drug Response. Clin Pharmacol Ther. 2018 02; 103(2):233-242. View in PubMed
- Zamek-Gliszczynski MJ, Giacomini KM, Zhang L. Emerging Clinical Importance of Hepatic Organic Cation Transporter 1 (OCT1) in Drug Pharmacokinetics, Dynamics, Pharmacogenetic Variability, and Drug Interactions. Clin Pharmacol Ther. 2018 05; 103(5):758-760. View in PubMed
- Fohner AE, Brackman DJ, Giacomini KM, Altman RB, Klein TE. PharmGKB summary: very important pharmacogene information for ABCG2. Pharmacogenet Genomics. 2017 11; 27(11):420-427. View in PubMed
- Relling MV, Krauss RM, Roden DM, Klein TE, Fowler DM, Terada N, Lin L, Riel-Mehan M, Do TP, Kubo M, Yee SW, Johnson GT, Giacomini KM. New Pharmacogenomics Research Network: An Open Community Catalyzing Research and Translation in Precision Medicine. Clin Pharmacol Ther. 2017 Dec; 102(6):897-902. View in PubMed
- Hsueh CH, Hsu V, Zhao P, Zhang L, Giacomini KM, Huang SM. PBPK Modeling of the Effect of Reduced Kidney Function on the Pharmacokinetics of Drugs Excreted Renally by Organic Anion Transporters. Clin Pharmacol Ther. 2018 03; 103(3):485-492. View in PubMed
- Stecula A, Schlessinger A, Giacomini KM, Sali A. Human Concentrative Nucleoside Transporter 3 (hCNT3, SLC28A3) Forms a Cyclic Homotrimer. Biochemistry. 2017 07 11; 56(27):3475-3483. View in PubMed
- Khuri N, Zur AA, Wittwer MB, Lin L, Yee SW, Sali A, Giacomini KM. Computational Discovery and Experimental Validation of Inhibitors of the Human Intestinal Transporter OATP2B1. J Chem Inf Model. 2017 06 26; 57(6):1402-1413. View in PubMed
- Liang X, Giacomini KM. Transporters Involved in Metformin Pharmacokinetics and Treatment Response. J Pharm Sci. 2017 09; 106(9):2245-2250. View in PubMed
- Cheung KWK, Hsueh CH, Zhao P, Meyer TW, Zhang L, Huang SM, Giacomini KM. The Effect of Uremic Solutes on the Organic Cation Transporter 2. J Pharm Sci. 2017 09; 106(9):2551-2557. View in PubMed
- Chen EC, Khuri N, Liang X, Stecula A, Chien HC, Yee SW, Huang Y, Sali A, Giacomini KM. Discovery of Competitive and Noncompetitive Ligands of the Organic Cation Transporter 1 (OCT1; SLC22A1). J Med Chem. 2017 04 13; 60(7):2685-2696. View in PubMed
- Dujic T, Zhou K, Yee SW, van Leeuwen N, de Keyser CE, Javorský M, Goswami S, Zaharenko L, Hougaard Christensen MM, Out M, Tavendale R, Kubo M, Hedderson MM, van der Heijden AA, Klimcáková L, Pirags V, Kooy A, Brøsen K, Klovins J, Semiz S, Tkác I, Stricker BH, Palmer C, 't Hart LM, Giacomini KM, Pearson ER. Variants in Pharmacokinetic Transporters and Glycemic Response to Metformin: A Metgen Meta-Analysis. Clin Pharmacol Ther. 2017 Jun; 101(6):763-772. View in PubMed
- Luizon MR, Eckalbar WL, Wang Y, Jones SL, Smith RP, Laurance M, Lin L, Gallins PJ, Etheridge AS, Wright F, Zhou Y, Molony C, Innocenti F, Yee SW, Giacomini KM, Ahituv N. Genomic Characterization of Metformin Hepatic Response. PLoS Genet. 2016 Nov; 12(11):e1006449. View in PubMed
- Giacomini KM, Yee SW, Mushiroda T, Weinshilboum RM, Ratain MJ, Kubo M. Genome-wide association studies of drug response and toxicity: an opportunity for genome medicine. Nat Rev Drug Discov. 2017 Jan; 16(1):1. View in PubMed
- Giacomini KM. The use of drug transporters as therapeutic targets. Clin Adv Hematol Oncol. 2016 Nov; 14(11):869-871. View in PubMed
- Irwin JJ, Pottel J, Zou L, Wen H, Zuk S, Zhang X, Sterling T, Shoichet BK, Lionberger R, Giacomini KM. A Molecular Basis for Innovation in Drug Excipients. Clin Pharmacol Ther. 2017 03; 101(3):320-323. View in PubMed
- Goswami S, Yee SW, Xu F, Sridhar SB, Mosley JD, Takahashi A, Kubo M, Maeda S, Davis RL, Roden DM, Hedderson MM, Giacomini KM, Savic RM. A Longitudinal HbA1c Model Elucidates Genes Linked to Disease Progression on Metformin. Clin Pharmacol Ther. 2016 Nov; 100(5):537-547. View in PubMed
- Yee SW, Giacomini MM, Hsueh CH, Weitz D, Liang X, Goswami S, Kinchen JM, Coelho A, Zur AA, Mertsch K, Brian W, Kroetz DL, Giacomini KM. Metabolomic and Genome-wide Association Studies Reveal Potential Endogenous Biomarkers for OATP1B1. Clin Pharmacol Ther. 2016 Nov; 100(5):524-536. View in PubMed
- Zur AA, Chien HC, Augustyn E, Flint A, Heeren N, Finke K, Hernandez C, Hansen L, Miller S, Lin L, Giacomini KM, Colas C, Schlessinger A, Thomas AA. LAT1 activity of carboxylic acid bioisosteres: Evaluation of hydroxamic acids as substrates. Bioorg Med Chem Lett. 2016 10 15; 26(20):5000-5006. View in PubMed
- Hsueh CH, Yoshida K, Zhao P, Meyer TW, Zhang L, Huang SM, Giacomini KM. Identification and Quantitative Assessment of Uremic Solutes as Inhibitors of Renal Organic Anion Transporters, OAT1 and OAT3. Mol Pharm. 2016 09 06; 13(9):3130-40. View in PubMed
- Zhou K, Yee SW, Seiser EL, van Leeuwen N, Tavendale R, Bennett AJ, Groves CJ, Coleman RL, van der Heijden AA, Beulens JW, de Keyser CE, Zaharenko L, Rotroff DM, Out M, Jablonski KA, Chen L, Javorský M, Židzik J, Levin AM, Williams LK, Dujic T, Semiz S, Kubo M, Chien HC, Maeda S, Witte JS, Wu L, Tkác I, Kooy A, van Schaik RHN, Stehouwer CDA, Logie L, MetGen Investigators, DPP Investigators, ACCORD Investigators, Sutherland C, Klovins J, Pirags V, Hofman A, Stricker BH, Motsinger-Reif AA, Wagner MJ, Innocenti F, 't Hart LM, Holman RR, McCarthy MI, Hedderson MM, Palmer CNA, Florez JC, Giacomini KM, Pearson ER. Variation in the glucose transporter gene SLC2A2 is associated with glycemic response to metformin. Nat Genet. 2016 09; 48(9):1055-1059. View in PubMed
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- Wu X, Hui AC, Giacomini KM. Formycin B elimination from the cerebrospinal fluid of the rat. Pharm Res. 1993 Apr; 10(4):611-5. View in PubMed
- Brett CM, Washington CB, Ott RJ, Gutierrez MM, Giacomini KM. Interaction of nucleoside analogues with the sodium-nucleoside transport system in brush border membrane vesicles from human kidney. Pharm Res. 1993 Mar; 10(3):423-6. View in PubMed
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- Frishman WH. Beta-adrenergic blockers as cardioprotective agents. Am J Cardiol. 1992 Dec 21; 70(21):2I-6I. View in PubMed
- Chang SW, Dutton D, Wang HL, He LS, Stearns R, Hui A, Giacomini KM, Ortiz de Montellano P, Voelkel NF. Intact lung cytochrome P-450 is not required for hypoxic pulmonary vasoconstriction. Am J Physiol. 1992 Oct; 263(4 Pt 1):L446-53. View in PubMed
- Wu X, Yuan G, Brett CM, Hui AC, Giacomini KM. Sodium-dependent nucleoside transport in choroid plexus from rabbit. Evidence for a single transporter for purine and pyrimidine nucleosides. J Biol Chem. 1992 May 05; 267(13):8813-8. View in PubMed
- Gutierrez MM, Brett CM, Ott RJ, Hui AC, Giacomini KM. Nucleoside transport in brush border membrane vesicles from human kidney. Biochim Biophys Acta. 1992 Mar 23; 1105(1):1-9. View in PubMed
- Ott RJ, Hui AC, Giacomini KM. Inhibition of N-linked glycosylation affects organic cation transport across the brush border membrane of opossum kidney (OK) cells. J Biol Chem. 1992 Jan 05; 267(1):133-9. View in PubMed
- Ott RJ, Hui AC, Yuan G, Giacomini KM. Organic cation transport in human renal brush-border membrane vesicles. Am J Physiol. 1991 Sep; 261(3 Pt 2):F443-51. View in PubMed
- Yuan G, Ott RJ, Salgado C, Giacomini KM. Transport of organic cations by a renal epithelial cell line (OK). J Biol Chem. 1991 May 15; 266(14):8978-86. View in PubMed
- Lam YW, Boyd RA, Chin SK, Chang D, Giacomini KM. Effect of probenecid on the pharmacokinetics and pharmacodynamics of procainamide. J Clin Pharmacol. 1991 May; 31(5):429-32. View in PubMed
- Whittico MT, Hui AC, Giacomini KM. Preparation of brush border membrane vesicles from bovine choroid plexus. J Pharmacol Methods. 1991 May; 25(3):215-27. View in PubMed
- Ott RJ, Hui AC, Wong FM, Hsyu PH, Giacomini KM. Interactions of quinidine and quinine and (+)- and (-)-pindolol with the organic cation/proton antiporter in renal brush border membrane vesicles. Biochem Pharmacol. 1991 Jan 01; 41(1):142-5. View in PubMed
- Whittico MT, Gang YA, Giacomini KM. Cimetidine transport in isolated brush border membrane vesicles from bovine choroid plexus. J Pharmacol Exp Ther. 1990 Nov; 255(2):615-23. View in PubMed
- Ott RJ, Hai AC, Giacomini KM. Mechanisms of interactions between organic anions and the organic cation transporter in renal brush border membrane vesicles. Biochem Pharmacol. 1990 Aug 01; 40(3):659-61. View in PubMed
- Koivukangas J, Louhisalmi Y. Computer-guided laser for neurosurgery. Ann Chir Gynaecol. 1990; 79(4):192-6. View in PubMed
- Boyd RA, Chin SK, Don-Pedro O, Verotta D, Sheiner LB, Williams RL, Giacomini KM. The pharmacokinetics and pharmacodynamics of diltiazem and its metabolites in healthy adults after a single oral dose. Clin Pharmacol Ther. 1989 Oct; 46(4):408-19. View in PubMed
- Chin SK, Hui AC, Giacomini KM. High-performance liquid chromatographic determination of the enantiomers of beta-adrenoceptor blocking agents in biological fluids. II. Studies with atenolol. J Chromatogr. 1989 Apr 14; 489(2):438-45. View in PubMed
- Gisclon LG, Boyd RA, Williams RL, Giacomini KM. The effect of probenecid on the renal elimination of cimetidine. Clin Pharmacol Ther. 1989 Apr; 45(4):444-52. View in PubMed
- Boyd RA, Chin SK, Don-Pedro O, Williams RL, Giacomini KM. The pharmacokinetics of the enantiomers of atenolol. Clin Pharmacol Ther. 1989 Apr; 45(4):403-10. View in PubMed
- Boyd RA, Giacomini JC, Giacomini KM. Species differences in the negative inotropic response of 1,4-dihydropyridine calcium channel blockers in myocardium. J Cardiovasc Pharmacol. 1988 Dec; 12(6):650-7. View in PubMed
- Whittico MT, Giacomini KM. Cimetidine elimination from the cerebrospinal fluid of the rat. Pharm Res. 1988 Oct; 5(10):628-33. View in PubMed
- Giacomini KM, Hsyu PH, Gisclon LG. Renal transport of drugs: an overview of methodology with application to cimetidine. Pharm Res. 1988 Aug; 5(8):465-71. View in PubMed
- Valdivieso L, Giacomini KM, Nelson WL, Pershe R, Blaschke TF. Stereoselective binding of disopyramide to plasma proteins. Pharm Res. 1988 May; 5(5):316-8. View in PubMed
- Hsyu PH, Wong FM, Giacomini KM. The effect of pindolol on the transport of L-lysine in renal brush border membrane vesicles. Drug Metab Dispos. 1988 May-Jun; 16(3):503-5. View in PubMed
- Gisclon LG, Giacomini KM. Inhibition of cimetidine transport by creatinine in luminal membrane vesicles prepared from rabbit kidney. Drug Metab Dispos. 1988 Mar-Apr; 16(2):331-2. View in PubMed
- Hsyu PH, Gisclon LG, Hui AC, Giacomini KM. Interactions of organic anions with the organic cation transporter in renal BBMV. Am J Physiol. 1988 Jan; 254(1 Pt 2):F56-61. View in PubMed
- Boyd RA, Giacomini JC, Wong FM, Nelson WL, Giacomini KM. Comparison of binding affinities and negative inotropic potencies of the 1,4-dihydropyridine calcium channel blockers in rabbit myocardium. J Pharmacol Exp Ther. 1987 Oct; 243(1):118-25. View in PubMed
- Gisclon L, Wong FM, Giacomini KM. Cimetidine transport in isolated luminal membrane vesicles from rabbit kidney. Am J Physiol. 1987 Jul; 253(1 Pt 2):F141-50. View in PubMed
- Hsyu PH, Giacomini KM. Essential tyrosine residues in transport of organic cations in renal BBMV. Am J Physiol. 1987 Jun; 252(6 Pt 2):F1065-72. View in PubMed
- Hsyu PH, Giacomini KM. The pH gradient-dependent transport of organic cations in the renal brush border membrane. Studies with acridine orange. J Biol Chem. 1987 Mar 25; 262(9):3964-8. View in PubMed
- Theodore LJ, Nelson WL, Zobrist RH, Giacomini KM, Giacomini JC. Studies on Ca2+ channel antagonists. 5-[(3,4-Dimethoxyphenethyl)methylamino]-2-(3,4-dimethoxyphenyl)-2- isopropylpentyl isothiocyanate, a chemoaffinity ligand derived from verapamil. J Med Chem. 1986 Sep; 29(9):1789-92. View in PubMed
- Zobrist RH, Giacomini KM, Nelson WL, Giacomini JC. The interaction of phenylalkylamine calcium channel blockers with the 1,4-dihydropyridine binding site. J Mol Cell Cardiol. 1986 Sep; 18(9):963-74. View in PubMed
- Giacomini KM, Nelson WL, Pershe RA, Valdivieso L, Turner-Tamiyasu K, Blaschke TF. In vivo interaction of the enantiomers of disopyramide in human subjects. J Pharmacokinet Biopharm. 1986 Aug; 14(4):335-56. View in PubMed
- Nuytinck JK, Goris JA, Redl H, Schlag G, van Munster PJ. Posttraumatic complications and inflammatory mediators. Arch Surg. 1986 Aug; 121(8):886-90. View in PubMed
- Hsyu PH, Giacomini KM. High performance liquid chromatographic determination of the enantiomers of beta-adrenoceptor blocking agents in biological fluids. I: Studies with pindolol. J Pharm Sci. 1986 Jun; 75(6):601-5. View in PubMed
- Giacomini JC, Nelson WL, Wong FM, Boyd R, Zobrist RH, Giacomini KM. Stereoselective interactions of 2-[(2',6'-dimethoxyphenoxyethyl)aminomethyl]-1,4-benzodioxane (WB-4101) with the calcium channel. Biochem Pharmacol. 1986 Feb 15; 35(4):716-8. View in PubMed
- Hsyu PH, Giacomini KM. Stereoselective renal clearance of pindolol in humans. J Clin Invest. 1985 Nov; 76(5):1720-6. View in PubMed
- Giacomini JC, Giacomini KM, Nelson WL, Harrison DC, Blaschke TF. Electrophysiology of the enantiomers of disopyramide in dogs. J Cardiovasc Pharmacol. 1985 Sep-Oct; 7(5):884-90. View in PubMed
- Giacomini JC, Nelson WL, Theodore L, Wong FM, Rood D, Giacomini KM. The pharmacokinetics and pharmacodynamics of d- and dl-verapamil in rabbits. J Cardiovasc Pharmacol. 1985 May-Jun; 7(3):469-75. View in PubMed
- Giacomini JC, Zobrist RH, Dave B, Giacomini KM. Verapamil interacts stereoselectively with the muscarinic receptor. Pharm Res. 1985 Mar; 2(2):94-5. View in PubMed
- Giacomini KM, Massoud N, Wong FM, Giacomini JC. Decreased binding of verapamil to plasma proteins in patients with liver disease. J Cardiovasc Pharmacol. 1984 Sep-Oct; 6(5):924-8. View in PubMed
- Giacomini KM, Wong FM, Tozer TN. Correction for Volume Shift during Equilibrium Dialysis by Measurement of Protein Concentration. Pharm Res. 1984 Jul; 1(4):179-81. View in PubMed
- Smith GA, Giacomini KM, Smith CT, Gregory PB, Robinson WS, Merigan TC, Blaschke TF. High-performance liquid chromatographic analysis of hypoxanthine arabinoside in plasma. J Chromatogr. 1984 May 11; 307(2):410-5. View in PubMed
- Giacomini KM, Blaschke TF. Effect of concentration-dependent binding to plasma proteins on the pharmacokinetics and pharmacodynamics of disopyramide. Clin Pharmacokinet. 1984 Jan; 9 Suppl 1:42-8. View in PubMed
- Schulz P, Turner-Tamiyasu K, Smith G, Giacomini KM, Blaschke TF. Amitriptyline disposition in young and elderly normal men. Clin Pharmacol Ther. 1983 Mar; 33(3):360-6. View in PubMed
- Schulz P, Abang A, Giacomini JC, Blaschke TF, Giacomini KM. Effect of heparin on the red blood cell-to-plasma concentration ratio of diphenylhydantoin and prazosin. Ther Drug Monit. 1983; 5(4):497-9. View in PubMed
- Schulz P, Giacomini KM, Luttrell S, Turner-Tamiyasu K, Blaschke TF. Effect of low doses of heparin on the plasma binding of phenytoin and prazosin in normal man. Eur J Clin Pharmacol. 1983; 25(2):211-4. View in PubMed
- Giacomini KM, Abang A, Blaschke TF. Calculation of drug concentration in plasma after equilibrium dialysis. Br J Clin Pharmacol. 1982 Nov; 14(5):752-4. View in PubMed
- Pollick C, Giacomini KM, Blaschke TF, Nelson WL, Turner-Tamiyasu K, Briskin V, Popp RL. The cardiac effects of d- and l-disopyramide in normal subjects: a noninvasive study. Circulation. 1982 Aug; 66(2):447-53. View in PubMed
- Smith GA, Schulz P, Giacomini KM, Blaschke TF. High-pressure liquid chromatographic determination of amitriptyline and its major metabolites in human whole blood. J Pharm Sci. 1982 May; 71(5):581-3. View in PubMed
- Swezey SF, Giacomini KM, Abang A, Brass C, Stevens DA, Blaschke TF. Measurement of ketoconazole, a new antifungal agent, by high-performance liquid chromatography. J Chromatogr. 1982 Feb 12; 227(2):510-5. View in PubMed
- Giacomini KM, Swezey SE, Turner-Tamiyasu K, Blaschke TF. The effect of saturable binding to plasma proteins on the pharmacokinetic properties of disopyramide. J Pharmacokinet Biopharm. 1982 Feb; 10(1):1-14. View in PubMed
- Nelson WL, Sneed CK, Giacomini KM, Giacomini JC, Stauss J, Blaschke TF, Cox BM. Synthesis and anticholinergic properties of the enantiomers of 4-(isopropylamino)-2-(2-pyridyl)-2-phenylbutyramide, the mono-N-dealkylated metabolite of disopyramide. J Med Chem. 1981 May; 24(5):614-7. View in PubMed
- Giacomini KM, Roberts SM, Levy G. Evaluation of methods for producing renal dysfunction in rats. J Pharm Sci. 1981 Feb; 70(2):117-21. View in PubMed
- Giacomini KM, Giacomini JC, Blaschke TF. Absence of effect of heparin on the binding of prazosin and phenytoin to plasma proteins. Biochem Pharmacol. 1980 Dec; 29(24):3337-40. View in PubMed
- Giacomini KM, Giacomini JC, Swezey SE, Harrison DC, Nelson WL, Burke TR, Blaschke TF. The stereoselective disposition of disopyramide in the dog. J Cardiovasc Pharmacol. 1980 Nov-Dec; 2(6):825-32. View in PubMed
- Giacomini KM, Cox BM, Blaschke TF. Comparative anticholinergic potencies of R- and S- disopyramide in longitudinal muscle strips from guinea pig ileum. Life Sci. 1980 Sep 29; 27(13):1191-7. View in PubMed
- Giacomini KM, Swezey SE, Giacomini JC, Blaschke TF. Administration of heparin causes in vitro release of non-esterified fatty acids in human plasma. Life Sci. 1980 Sep 01; 27(9):771-80. View in PubMed
- Giacomini KM, Giacomini JC, Gibson TP, Levy G. Propoxyphene and norpropoxyphene plasma concentrations after oral propoxyphene in cirrhotic patients with and without surgically constructed portacaval shunt. Clin Pharmacol Ther. 1980 Sep; 28(3):417-24. View in PubMed
- Giacomini KM, Nakeeb SM, Levy G. Pharmacokinetic studies of propoxyphene I:Effect of portacaval shunt on systemic availability in dogs. J Pharm Sci. 1980 Jul; 69(7):786-9. View in PubMed
- Gibson TP, Giacomini KM, Briggs WA, Whitman W, Levy G. Propoxyphene and norpropoxyphene plasma concentrations in the anephric patient. Clin Pharmacol Ther. 1980 May; 27(5):665-70. View in PubMed
- Giacomini KM, Gibson TP, Levy G. Effect of hemodialysis on propoxyphene and norpropoxyphene concentrations in blood of anephric patients. Clin Pharmacol Ther. 1980 Apr; 27(4):508-14. View in PubMed
- Jones MR, Kopple JD, Swendseid ME. Phenylalanine metabolism in uremic and normal man. Kidney Int. 1978 Aug; 14(2):169-79. View in PubMed
- Levy G, Giacomini KM. Rational aspirin dosage regimens. Clin Pharmacol Ther. 1978 Mar; 23(3):247-52. View in PubMed
- Giacomini KM, Gibson TP, Levy G. Plasma protein binding of d-propoxyphene in normal subjects and anephric patients. J Clin Pharmacol. 1978 Feb-Mar; 18(2-3):106-9. View in PubMed
- Soles C, Giacomini KM, Roberts SM, Giacomini JC. Soles C, Giacomini KM, Roberts SM, Giacomini JC.. A Convenient Method for Repetitive Blood Sampling in the Dog. J. Pharmacol. Meth. 1978; (1):259-261. View in PubMed
- Senet JM, Robert R, Mauras G. [Diagnosis of toxoplasmosis by indirect hemagglutination. II. Value of mixed total antigen fixation in the presence of glutaraldehyde in the early diagnosis of the disease]. Biomedicine. 1976 Jul; 25(6):212-4. View in PubMed